UK-wide

If you place hazardous mixtures on the Great Britain market, you must submit information about those mixtures to the National Poisons Information Service (NPIS). This information enables the NPIS to provide emergency medical advice when poisoning incidents occur.

This obligation comes from Article 45 of the GB CLP Regulation (retained EU Regulation (EC) No 1272/2008 as amended for Great Britain). It applies to importers and downstream users who place hazardous mixtures on the GB market.

Note: HSE announced on 3 February 2022 that the arrangements for making submissions to the NPIS are under review. The submission process described in this guide reflects the current known requirements, but you should check the HSE poison centres page for the latest guidance before submitting.

When notification is required

You must notify the NPIS if you are an importer or downstream user placing a mixture on the GB market that is classified as hazardous based on its:

  • Health effects - acute toxicity, skin corrosion or irritation, serious eye damage or irritation, respiratory or skin sensitisation, germ cell mutagenicity, carcinogenicity, reproductive toxicity, specific target organ toxicity, aspiration hazard
  • Physical effects - explosives, flammable gases, liquids or solids, oxidising substances, organic peroxides, self-reactive substances, corrosive to metals

Mixtures classified as hazardous only for environmental effects (e.g. hazardous to the aquatic environment) are generally exempt from NPIS notification.

Timing

Notification must be made before or at the time you first place the hazardous mixture on the GB market. You should not place a notifiable mixture on the market until the submission has been made.

Unique Formula Identifier (UFI)

The Unique Formula Identifier (UFI) is a 16-character alphanumeric code that uniquely links a product to its composition information held by a poison centre.

UFI in Great Britain

Unlike the EU, there is no legal obligation to generate or include a UFI on product labels in Great Britain. However:

  • If you have already generated a UFI (for example, because you also sell the product in the EU or Northern Ireland), the NPIS will register it alongside your product notification
  • Using a UFI can speed up emergency responses by allowing the NPIS to quickly identify the exact product formulation
  • If you supply products into both GB and EU/NI markets, using the same UFI across markets simplifies your compliance

UFI in Northern Ireland

Northern Ireland follows EU CLP under the Windsor Framework. For mixtures placed on the Northern Ireland market, the UFI is mandatory and must appear on the label for consumer and professional use mixtures, or in Section 1.1 of the Safety Data Sheet for industrial use mixtures. These submissions go to the ECHA Poison Centres Notification (PCN) portal, not the NPIS.

NPIS submission format

For GB market notifications, the current recommended approach is to submit information by email to the NPIS. Your submission should include:

  1. Product identification: trade name, any alternative names or brand names under which the mixture is sold, and the product category (consumer, professional, or industrial use)
  2. Full composition: the identity and concentration of every component in the mixture, including non-hazardous components. Use CAS numbers and IUPAC names where possible
  3. Classification and labelling: the GB CLP classification of the mixture, including hazard class, category, hazard statements, and pictograms
  4. Toxicological information: known health effects, first aid measures, and any clinical experience or case reports
  5. Packaging details: types of packaging, sizes, closure types, and whether child-resistant fastening is used
  6. Supplier details: your company name, address, telephone number, and emergency contact information

Confidentiality: The NPIS treats all composition information as confidential. It is used solely for emergency health response and is not disclosed publicly or to competitors.

When to update your notification

You must update your NPIS notification whenever:

  • The composition of the mixture changes (including changes to concentration ranges of hazardous components)
  • The classification of the mixture changes (e.g. due to reclassification of a component substance or updated toxicological data)
  • New toxicological information becomes available that affects the emergency response advice
  • The product identifier changes (new trade name or product code)
  • The supplier details change (company name, address, or emergency contact number)

Updates should be submitted promptly. There is no specified deadline in GB CLP for submitting updates, but good practice is to update the NPIS before or at the time the changed product is first supplied.

Penalties for non-compliance

Failure to notify the NPIS as required is an offence under the CLP Enforcement Regulations. Penalties include:

  • Summary conviction: a fine not exceeding the statutory maximum and/or imprisonment up to 3 months
  • Conviction on indictment: an unlimited fine and/or imprisonment up to 2 years

HSE and local authority Trading Standards officers enforce these requirements. They may inspect your records, request evidence of NPIS notification, and take enforcement action if you have placed notifiable mixtures on the market without submitting the required information.

Warning If you also supply hazardous mixtures into Northern Ireland or the EU, you must make separate notifications through the ECHA Poison Centres portal using the Annex VIII format. GB and EU/NI notification requirements are different and compliance with one does not satisfy the other.