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Chemicals compliance in the UK

Complete guide to UK REACH and GB CLP compliance for businesses that manufacture, import, or use chemical substances and mixtures.

Running a Business Updated 15 September 2026
references 5 guides

Understanding UK chemicals regulation

If your business manufactures, imports, or uses chemical substances in Great Britain, you must comply with two core regulatory frameworks: UK REACH and GB CLP. These are the UK's independent versions of the EU chemicals regulations, enforced by the Health and Safety Executive (HSE).

This learning path takes you through each obligation step by step, from registration through to hazard labelling and poison centre notification. By the end, you will understand your duties and where to find detailed guidance for each requirement.

Phase 1: UK REACH registration

UK REACH requires manufacturers and importers of chemical substances to register them with HSE. If you grandfathered an existing EU REACH registration in 2021, you must now submit full registration data within the transitional deadlines.

Register chemicals under UK REACH

Full guidance on UK REACH registration requirements, tonnage bands, deadlines, fees, and your obligations as a registrant. Essential reading for manufacturers and importers of chemical substances in Great Britain.

Phase 2: Your role in the supply chain

Not every business handling chemicals needs to register them. If you use chemical substances supplied by others, you are likely a downstream user under UK REACH. Downstream users have distinct obligations including following Safety Data Sheet instructions, adhering to exposure scenarios, and communicating information up the supply chain.

UK REACH obligations for downstream users

How to comply with UK REACH as a downstream user. Covers Safety Data Sheet compliance, exposure scenario adherence, SVHC communication duties, and record-keeping requirements.

Phase 3: Substances of Very High Concern

Certain chemicals are identified as Substances of Very High Concern (SVHCs) because they pose serious risks to human health or the environment. UK REACH maintains its own Candidate List, which is diverging from the EU list. If your products contain SVHCs above 0.1% by weight, you have specific notification and communication obligations.

SVHC obligations under UK REACH

How to identify, notify, and communicate about Substances of Very High Concern. Covers the UK Candidate List, Article 33 duties, authorisation requirements, and how the UK and EU SVHC lists are diverging.

Phase 4: Classification and labelling under GB CLP

All hazardous substances and mixtures placed on the GB market must be classified, labelled, and packaged according to the GB CLP Regulation. This determines what hazard pictograms, signal words, and precautionary statements appear on your product labels and Safety Data Sheets.

Classify and label chemicals for the GB market

How to classify, label, and package hazardous chemicals under GB CLP, including the GB Mandatory Classification and Labelling list, Safety Data Sheet requirements, and ongoing notification obligations.

Phase 5: Poison centre notification

If you place hazardous mixtures on the GB market, you must notify the National Poisons Information Service (NPIS) with detailed composition information. This allows medical professionals to provide accurate treatment advice in poisoning emergencies. Notifications must include a Unique Formula Identifier (UFI) that links each product to its registered composition.

Notify hazardous mixtures to the NPIS

When and how to submit poison centre notifications for hazardous mixtures, including the Unique Formula Identifier requirement, submission format, update triggers, and penalties for non-compliance.

What you should now understand

After completing this learning path, you should understand:

  • How UK REACH registration works and the transitional deadlines that apply
  • Your obligations as a downstream user of chemical substances
  • SVHC identification, notification, and supply chain communication duties
  • How to classify and label hazardous chemicals under GB CLP
  • When poison centre notification is required and how to submit it

Chemicals regulation is evolving as the UK develops its independent framework. HSE publishes updates to the UK Candidate List, GB MCL list, and registration guidance regularly. Monitor the HSE chemicals pages for changes affecting your substances.