UK Statutory Instrument 2025 United Kingdom

Medicines for Human Use (Clinical Trials) (Amendment) Regulations 2025

What this means for your business

2 obligations
1 penalties
1 guides
Enforced by
MHRA, CQC
Applies to
United Kingdom
On this page
2 compliance obligations, 1 practical guide
Read full text on legislation.gov.uk

What you must do

2 compliance obligations under this legislation.

Management duties 1

Maintain records of serious adverse events and manage related risks

If your company sponsors a clinical trial, you must keep detailed records of any serious adverse events or reactions that occur, both in the UK and in overseas trials that meet the specified conditions. You also need to assess these events promptly, investigate the risks and put in place actions to minimise or prevent them.

Trader/Business s.23 ICO When you are the sponsor of a clinical trial (in the UK …

Offences and prohibitions 1

Supply non‑investigational medicinal product with non‑compliant labeling for a clinical trial

If you (as a sponsor or any other person) sell, supply or arrange the sale of a medicinal product that is not part of the trial and the product’s label does not meet the requirements of regulation 46A, you commit a criminal offence. The sponsor offence does not require proof of knowledge, whereas the offence for other persons does. Conviction can lead to fines and/or imprisonment, but the exact penalties are set elsewhere in the regulations.

Any Person s.34 MHRA

Penalties for non-compliance

1 penalty under this legislation.

Fine

Supply non‑investigational medicinal product with non‑compliant labeling for a clinical trial

Penalty applies

s.34 Penalises: Supply non‑investigational medicinal product with non‑compliant labeling for …

Practical guidance

Our guides explain how to comply with the requirements above.

Sections and provisions

45 classified provisions from this legislation.

Duties 1

  • s.23 Insertion of new regulation A32 A sponsor

Offences and penalties 1

  • s.34 Amendment to regulation 49

Powers 1

  • s.16 Substitution of regulation 27B

Definitions 4

  • s.10 Substitution of regulation 11
  • s.11 Insertion of new regulations 11A and 11B
  • s.36 Amendment to regulation 58
  • s.45 Insertion of Schedule 14

Exemptions 4

  • s.9 Substitution of regulation 9
  • s.14 Substitution of regulations 14 to 26
  • s.28 Insertion of new regulation 37A
  • s.32 Substitution of Part 7